CBD What Does the Science Say?

A comprehensive review of the scientific literature on the possible benefits of CBD, describing findings from both preclinical and human clinical studies.

CBD (cannabidiol), a nonintoxicating compound derived from the cannabis plant, can be found in products ranging from lotion and smoothies to chewable gummies and pet treats. It’s been promoted—but not always scientifically validated—as a treatment for medical conditions including psychosis, anxiety, pain, and even cancer. This book by three leading cannabis researchers looks at the science of CBD. It offers a comprehensive review of the scientific literature on the possible benefits of CBD, describing findings from both preclinical and human clinical studies. 
 
The authors report that the current CBD fad has some basis in preclinical animal research that indicates potential beneficial effects. Clinical studies, hampered by regulations governing research with cannabis, have lagged behind the basic animal research. The authors examine what research shows about chemical and pharmacological aspects of CBD and CBD’s interaction with THC, the main psychotropic compound found in cannabis. They go on to review current state of knowledge about CBD’s effectiveness in treating epilepsy, cancer, nausea, pain, anxiety, PTSD, depression, sleep disorders, psychosis, and addiction.
 

Linda A. Parker is Professor Emeritus in the Psychology and Collaborative Neuroscience Program at the University of Guelph and the author of Cannabinoids and the Brain (MIT Press).
 
Erin M. Rock is a Postdoctoral Fellow and Adjunct Faculty member in the Psychology and Collaborative Neuroscience Program at the University of Guelph. 
 
Raphael Mechoulam, often called “the father of cannabis research,” is Lionel Jacobson Professor of Medicinal Chemistry at Hebrew University and winner of the 2019 Harvey Prize for outstanding contributions to science and technology.
 

Preface vii
1 Introduction 1
2 Chemical and Pharmacological Aspects 11
3 CBD/THC Interactions 39
4 Epilepsy 53
5 Neuroprotection, Tissue Protection, and Cancer 63
6 Nausea, Vomiting, and Appetite 97
7 Pain and Inflammation 117
8 Anxiety 149
9 PTSD, Depression and Sleep 163
10 Psychosis and Schizophrenia 181
11 Addiction 195
12 Conclusion 207
References 221
Index 301