The Evolution of HIV

Format: Hardcover
Pub. Date: 1999-06-01
Publisher(s): Johns Hopkins Univ Pr
List Price: $90.00

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The HIV epidemic has spawned a scientific effort unprecedented in the history of infectious disease research. This effort has merged aspects of clinical research, basic molecular biology, immunology, cell biology, epidemiology, and mathematical biology in ways that have not been seen before. In The Evolution of HIV Keith A. Crandall brings together researchers from these disciplines to present perspectives on both the molecular biology and molecular evolution of HIV. The book is organized into three sections: "Introduction to HIV" explores the fundamentals of the virus's molecular biology and its global diversity. "Molecular Methods for Studying HIV Diversity" looks at such topics as HIV phylogenetics, modeling the molecular evolution of HIV sequences, the use of phylogenetic inference to test an HIV transmission hypothesis, and coalescent approaches to HIV population genetics. The third section,"Case Studies of HIV Evolution" examines the levels of diversity within and among host individuals, the phylogenetics of known transmission histories, and HIV evolution and disease progression via longitudinal studies. The book will be of interest to researchers and clinicians working on HIV, as well as scientists studying molecular evolution, population genetics, and evolutionary biology. Contributors are John M. Coffin, Keith A. Crandall, Joseph Felsenstein, Walter M. Fitch, Brian Foley, Esther Guzman, Paul H. Harvey, David M. Hillis, Edward C. Holmes, Marcia L. Kalish, Bette T. M. Korber, Julia Krushkal, Carla L. Kuiken, Gerald H. Learn, Thomas Leitner, Wen-Hsiung Li, Francine E. McCutchan, Spencer V. Muse, Oliver G. Pylons, Allen G. Rodrigo, Raj Shankarappa, Richard W. Steketee, Alan R. Templeton, Donald M. Thea, Raphael P. Viscidi, Steven M. Wolinsky.

Table of Contents

Contributors vii(4)
Preface xi
Part I Introduction to HIV 3(102)
Chapter 1 Molecular Biology of HIV
John M. Coffin
Chapter 2 Global Diversity in HIV
Francine E. McCutchan
Part II Molecular Methods for Studying HIV Diversity 105(170)
Chapter 3 Phylogenetics and the Study of HIV
David M. Hillis
Chapter 4 Modeling the Molecular Evolution of HIV Sequences
Spencer V. Muse
Chapter 5 Statistical Approaches to Detecting Recombination
Keith A. Crandall
Alan R. Templeton
Chapter 6 The Molecular Population Dynamics of HIV-1
Eddie C. Holmes
Oliver G. Pybus
Paul H. Harvey
Chapter 7 Use of Phylogenetic Inference to Test an HIV Transmission Hypothesis
Julia Krushkal
Wen-Hsiung Li
Chapter 8 Coalescent Approaches to HIV Population Genetics
Allen G. Rodrigo
Joseph Felsenstein
Part III Case Studies of HIV Evolution 275(216)
Chapter 9 Levels of Diversity within and among Host Individuals
Steven M. Wolinsky
Gerald H. Learn
Chapter 10 The Phylogenetics of Known Transmission Histories
Thomas Leitner
Walter M. Fitch
Chapter 11 HIV Evolution and Disease Progression via Longitudinal Studies
Raphael P. Viscidi
Chapter 12 Perinatal HIV Infection
Marcia L. Kalish
Donald M. Thea
Richard W. Steketee
Chapter 13 Determinants of HIV-1 Protein Evolution
Carla L. Kuiken
Brian Foley
Esther Guzman
Bette T. M. Korber
Chapter 14 Evolution of HIV-1 Resistance to Antiviral Agents
Raj Shankarappa
Index 491

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