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Ketamine, approved in 2019 by the Food and Drug Administration for the treatment of depression, has been touted by scientists and media reports as something approaching a miracle cure. This volume in the MIT Press Essential Knowledge series chronicles the ascent of a drug that has been around for fifty years--in previous incarnations, a Vietnam-era combat anesthetic and a popular club drug--that has now been reinvented as a treatment for depression. Bita Moghaddam, a leading researcher in neuropharmacology, explains the scientific history and the biology of ketamine, its clinical use, and its recently discovered antidepressant effects, for the nonspecialist reader.
Table of Contents
1 The Molecule Ketamine 1
2 Uses of Ketamine 17
3 Neuroscience of Ketamine 31
4 Ketamine as an Antidepressant 65
5 How Does Ketamine Produce Antidepressant Effects? 101
6 Safety Concerns with Ketamine and Esketamine 121
7 Where Do We Go from Here? 141
Further Reading 177
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